To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

Constructive Bio has secured the exclusive licence to groundbreaking ‘tRNA Display’ technology from the MRC Laboratory of Molecular Biology. Innovations from the MRC such as tRNA Display technology ...

In December 2024, Alltrna announced its first development candidate, AP003, an engineered tRNA formulated in a lipid nanoparticle. This candidate is designed to restore protein production in patients ...

The natural and overlapping history of tRNA and rRNA reveals that: (1) the tRNA cloverleaf structure unfolded prior to the appearance of a fully functional ribosomal core, (2) the primordial role of ...

Four-base codon strategy was applied to incorporate a fluorophore−quencher pair into specific positions on a single protein; β-anthraniloyl-l-α,β-diaminopropionic acid (atnDap) was employed as a ...