To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

Here, the authors use cryo-EM to show how one of the monitoring bases of the ribosome enables a frameshift-inducing tRNA to instead read a 2-base codon.

In December 2024, Alltrna announced its first development candidate, AP003, an engineered tRNA formulated in a lipid nanoparticle. This candidate is designed to restore protein production in patients ...

Trbp111 is a 111 amino acid Aquifex aeolicus structure‐specific tRNA‐binding protein that has homologous counterparts distributed throughout evolution. A dimer is the functional unit for binding a ...

Constructive Bio has secured the exclusive licence to groundbreaking ‘tRNA Display’ technology from the MRC Laboratory of Molecular Biology. Innovations from the MRC such as tRNA Display technology ...

Four-base codon strategy was applied to incorporate a fluorophore−quencher pair into specific positions on a single protein; β-anthraniloyl-l-α,β-diaminopropionic acid (atnDap) was employed as a ...

The natural and overlapping history of tRNA and rRNA reveals that: (1) the tRNA cloverleaf structure unfolded prior to the appearance of a fully functional ribosomal core, (2) the primordial role of ...

The identification of SLC35F2 as the eukaryotic transporter of queuine and queuosine is key to understanding how these micronutrients are salvaged from the human gut and distributed to different body ...