Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment. Nature Aging , 2022; DOI: 10.1038/s43587-022-00290-0 Cite This Page : ...

The analysis of the structure of U1 snRNP (Pomeranz Krummel et al, 2009; Kondo et al, 2015) and the sequence of the U1 snRNA revealed that stem‐loop 3, which is solvent accessible and free of any ...

As a pivotal regulator of 5’ splice site recognition, U1 small nuclear ribonucleoprotein (U1 snRNP)-specific protein C (U1C) regulates pre-mRNA splicing by interacting with other components of the U1 ...

SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes. Nucleic Acids Research , 2021; 49 (10): 5845 DOI: 10.1093/nar/gkab386 Cite This Page : ...

Figure 1. Structural model of the human tri-snRNP in two different orientations. Left: An overview of the human tri-snRNP, including all RNA/protein components.Right: Rotated view of the model, ...

Deposition and dysfunction of U1 small nuclear ribonucleoprotein (snRNP) have been revealed in Alzheimer’s disease (AD), but whether U1 is involved in the amyloid precursor protein (APP) and Tau ...

However, these activities have typically been studied using noncognate helicase-substrate systems, because the in vivo targets of many helicases are unknown. We investigated how the Brr2 protein ...

Prp3 is an essential U4/U6 di-snRNP-associated protein whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood. We show by structural and biochemical analyses ...

U1 snRNP binds to the 5′ exon-intron junction of pre-mRNA and thus plays a crucial role at an early stage of pre-mRNA splicing. We present two crystal structures of engineered U1 sub-structures, which ...

Department of Biochemistry and Molecular Biophysics, Washington University Medical School, St. Louis, Missouri 63110, United States *Department of Biochemistry and Molecular Biophysics, Washington ...