In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

The FDA has approved Evrysdi in tablet form for patients with spinal muscular atrophy aged 2 years and older who weigh more ...

Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...

How does the splicing machinery distinguish between exons, which are part of the mature mRNA, and introns, which are removed from the pre-mRNA? Alternative splicing adds an extra layer of ...

is correctly assembled into mature mRNA. Splicing is a basic requirement for producing proteins that fulfill an organism's ...

"Previously, we tended to think of splicing as a constant—you make a pre-mRNA; you splice it. Now we know that the physical organization of the nucleus makes a big difference in the efficiency ...

The 5 mg risdiplam tablet provides the same efficacy and safety for spinal muscular atrophy as the currently available oral ...

Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with poor prognosis, and understanding the ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

HNRNPC, known for its role in pre-mRNA splicing, was found to enhance the inclusion of BOLA3 exon 3, leading to increased BOLA3 protein levels and promoting ESCC cell proliferation, migration ...

In a recent article, he showed that when genes are preferentially positioned near speckles, mRNA splicing is significantly more efficient. 4 “It’s huge for the RNA processing field, because now it ...