A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

Then the RNA binding protein communicates to the splicing machinery to include or not include the exon into the mRNA,” Cooper explained. The fit between a splice site and the spliceosome components ...

Spliceosomes act as an editing tool, helping to make sense of the fragmented messages stored in pre-mRNA. Most genes have many introns that belong to one class – the major introns – which are removed ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

Plants survive cold by adjusting at cellular level. Scientists discovered that the PORCUPINE protein helps plants adapt to ...