We characterized back-splicing cis- and trans-elements, and found viral circRNAs resistant to spliceosome perturbation and lacking canonical splice donor-acceptors. Subsequent loss-of-function studies ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Plants survive cold by adjusting at cellular level. Scientists discovered that the PORCUPINE protein helps plants adapt to ...

Proper splicing requires efficient spliceosome assembly ... Ribosome ubiquitination regulates HAC1 mRNA processing during the unfolded protein response. Here, the authors show that the SCFGrr1 ...

Spliceosome structures have been investigated extensively in the past decade, but most of the studies have been restricted to ...

Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are evident in the brain and spinal cord of patients that present across a spectrum of neurodegenerative diseases. For ...

Pancreatic cancer is one of the deadliest cancers. But those battling the disease saw promising results in the small clinical trial of an mRNA vaccine.

A team at Memorial Sloan Kettering has been working to improve those outcomes by developing a new mRNA vaccine for pancreatic cancer. A few years ago, the team embarked on a small trial to test the ...

The researchers now plan to further analyze the structures formed by the interactions of Luc7 proteins with mRNA and the rest of the spliceosome, which could help them figure out in more detail ...

The Montana House on Wednesday voted down a bill that would have banned mRNA vaccines statewide, including the Covid-19 vaccine. After passing out of committee on a party line vote last week ...

Vaccines using messenger RNA, or mRNA, technology became widespread during the pandemic. With limited long-term studies available, the Trump administration is revisiting these vaccines. In response to ...