A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

The Spliceosome Comes Assembled Graphic: Courtesy of Scott Stevens ASSEMBLY INSTRUCTIONS: In the penta-snRNP model, all five spliceosomal snRNPs interact with the substrate pre-mRNA as a single, ...

Researchers unveil detailed structural insights into the minor spliceosome, shedding light on its role in gene expression and potential disease implications.

What we know about the safety, efficacy of mRNA vaccines amid recent scrutiny Vaccines using mRNA technology have been studied for decades, experts say.

The researchers now plan to further analyze the structures formed by the interactions of Luc7 proteins with mRNA and the rest of the spliceosome, which could help them figure out in more detail ...

The authors show that after the spliceosome is finished splicing the mRNA, it remains active and can engage in further reactions with the removed introns. This discovery provides the strongest ...

This parallel pre-mRNA splicing machinery functions during the nuclear RNA processing phase and regulates cellular mRNA levels. We investigate the mechanism, regulation and genomics/transcriptomics, ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a ...