A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

The researchers now plan to further analyze the structures formed by the interactions of Luc7 proteins with mRNA and the rest of the spliceosome, which could help them figure out in more detail ...

The spliceosome then converts them into mature, functional mRNA. To do this, this large protein-RNA complex, which is located in the cell nucleus, removes non-coding sections (introns) from mRNA ...

Then the RNA binding protein communicates to the splicing machinery to include or not include the exon into the mRNA,” Cooper explained. The fit between a splice site and the spliceosome components ...

Proper splicing requires efficient spliceosome assembly ... a key component of nonsense-mediated mRNA decay (NMD), during cellular senescence and its impact on NMD efficiency, leading to the ...

Spliceosomes act as an editing tool, helping to make sense of the fragmented messages stored in pre-mRNA. Most genes have many introns that belong to one class – the major introns – which are removed ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

National Institutes of Health officials have urged scientists to remove all references to mRNA vaccine technology from their grant applications, two researchers said, in a move that signaled the ...