Compared to the standard shot, the mRNA vaccine had an overall vaccine efficacy that was 26.6 percent higher, and 27.4 ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

A more effective vaccine technology may be on the horizon. In a new study in mice, researchers from the University of ...

Additionally, it dramatically increased antibody titer by up to 128-fold in vivo, compared to the codon-optimization benchmark mRNA sequence H.

The team then redesigned mRNA sequences to avoid these ‘off-target’ effects, by correcting the error-prone genetic sequences in the synthetic mRNA. This produced the intended protein.” At issue is a ...

Research led by Duke University, Durham, has discovered a situation-dependent traffic jam in mRNA translation caused by RNA hairpins leading to higher translation of upstream start codons (uAUGs).

A research team from The University of Osaka and the Institute of Science Tokyo has developed a class of mRNA medicines that ...

Ribosomes translocate along the mRNA strands one codon at a time. Codons are three nucleotide sequences in RNA that correspond to an amino acid; each codon binds to a tRNA molecule carrying the ...

The tRNA translates the mRNA codon sequence into a growing chain of amino acids that will become a protein. A codon is a sequence of three consecutive DNA or RNA nucleotides that corresponds with ...

mRNA display is an entire in vitro selection method that takes advantage of cell-free translation systems for the generation of polypeptide sequences. Both the expression and the selection are ...