Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44 , 283–292 (1986) An analysis of 5'-noncoding sequences from 699 ...

Scientists explored mRNA and protein public databases to unravel hidden meanings of the genetic code. Using a metric derived from mRNA codon composition, they found out how gene sequence choice ...

Additionally, it dramatically increased antibody titer by up to 128-fold in vivo, compared to the codon-optimization benchmark mRNA sequence H.

For example, if the base sequence is GGGAAACCC, reading could start from the first letter, G and there will be 3 codons - GGG, AAA, and CCC. If reading starts at G in the second position, the ...

Researchers set out to find new ways to artificially induce mRNA to respond in ways that could eventually lead to therapeutic outcomes, expanding on the success of the mRNA-based COVID-19 vaccines.

Their study design pitted a dozen RNA sequences, ... "For example, they could use UUG start codon and chemically modify mRNA by 1m Psi, as Pfizer did with their COVID-19 vaccine.

Ribosome translating mRNA WIKIMEDIA, NICOLLE RAGER, NATIONAL SCIENCE FOUNDATION Interruption of the protein translation machinery as it reads a messenger RNA (mRNA) transcript is rare but problematic.

Using a metric derived from mRNA codon composition, they found out how gene sequence choice can predict different aspects of protein synthesis, such as protein production efficiency.