This AI system can analyze up to one million DNA letters at once, predicting how tiny changes in noncoding regions trigger ...

DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease ...

When people think of DNA, they usually think of genes, the parts that code for proteins and drive inherited traits. But there ...

Every living cell must interpret its genetic code—a sequence of chemical letters that governs countless cellular functions. A ...

A splicing code task is then to take in the genomic sequence in the region encompassing an AS event such as the cassette illustrated in Figure 1c and output a condition-specific PSI or dPSI for ...

Long non-coding RNAs (lncRNAs) are a class of transcripts that generally exhibit a lower degree of sequence conservation when compared to protein-coding or small non-coding RNAs. Such conservation can ...

Discovering the Functions of Noncoding Sequence Variants Neville Sanjana explored noncoding genomic regions by combining pooled CRISPR screening and single cell sequencing.

A more accurate and inclusive edition of our genetic code was published Wednesday, marking a major step toward a deeper understanding of human biology and personalized medicine for people from a ...

Periodicities within the genomic sequences play an important role in understanding the structural and functional behavior of DNA signals. The three-base periodicity (TBP) inherent to protein-coding ...

Thousands of short RNA sequences that code for microproteins and peptides have been identified, opening new avenues for disease research and drug development.

An online tool reveals the extent of gene-restructuring events in noncoding sequences. An interactive web portal developed by scientists at KAUST offers a platform for cancer researchers to ...

Despite having very similar amino acid sequences, two forms of the protein actin have distinct roles in the body. A Penn Vet-led team showed that differences in the coding sequence of nucleotides ...