The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps")—and about 150 proteins, involved in different stages of ...

The spliceosome then converts them into mature, functional mRNA. To do this, this large protein-RNA complex, which is located ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

Think of the spliceosome as an old Transformers robot — it has individual pieces that operate independently but can also come together to form a larger structure. Sometimes, such as in the case of ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules that orchestrate the RNA editing process, but until now, ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different versions of a protein from a single gene. The vast majority of human genes -- more than nine in ten ...

Romancing the Spliceosome to Fight Spinal Muscular Atrophy. Author: Kathryn J. Swoboda, M.D. Author Info & Affiliations. Published October 30, 2014. N Engl J Med 2014; 371: 1752-1754.

Precursor messenger RNA is edited into its final form by an RNA–protein assembly called the spliceosome. Structural evidence provides insights into how the spliceosome is disassembled when its ...

The spliceosome is best known for shepherding primary messenger RNA transcripts to maturity. This enzyme complex also contributes to the synthesis of an enzyme that maintains chromosome ends.

The spliceosome does the genetic cutting and pasting. It is a complicated complex, made up of four major parts and more than 100 accessory proteins that come together and break apart throughout ...