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The major spliceosome is abundant in cells and has been extensively investigated for more than four decades. Its long-separated twin – the minor spliceosome, is much more scarce and remains enigmatic, ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") – and about 150 proteins, involved in different stages ...

Spliceosome, synaptic, and ECM proteins were all associated with cognitive decline. The authors compared their findings with CSF data from 35 people with progressive supranuclear palsy, a primary ...

The spliceosome then converts them into mature, functional mRNA. To do this, this large protein-RNA complex, which is located in the cell nucleus, removes non-coding sections (introns) from mRNA ...

Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology, 2025; DOI: 10.1038/s41594-024-01480-7 ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

Running deep neural networks (DNNs) on large-scale videos from widely distributed cameras presents two significant challenges. Firstly, video quality for analytical purposes is severely impacted by ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different versions of a protein from a single gene. The vast majority of human genes – more than nine in ten – are ...