WE would like to report a simple method of synthesizing oxetanes. Oxetanes have generally been prepared by a multi-step procedure involving the basic elimination of a halide or acyl radical.
We intended to realize aryl vinyl oxetane as a 4Ï€-electrocyclization precursor to access indene ethanol. Interestingly, we found that the readily accessible aryl vinyl 1,3-diol, an intermediate en ...
Chemical Research and Development, Pfizer, Discovery Park, Sandwich CT13 9NJ, Kent, U.K.