eLife5d
Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines
Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.
AHA/ASA Journals1d
Lymphatic Endothelial Branched-Chain Amino Acid Catabolic Defects Undermine Cardiac Lymphatic Integrity and Drive HFpEF
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but ...
Gut1d
Tumour-intrinsic alterations and stromal matrix remodelling promote Wnt-niche independence during diffuse-type gastric cancer progression
Background Development of diffuse-type gastric cancer (DGC) starts with intramucosal lesions that are primarily composed of ...
AlphaGalileo5d
Inhibiting Sphingosine-1-Phosphate Receptor 3 (S1PR3) Mitigates Pulmonary Fibrosis
Pulmonary fibrosis (PF) involves the excessive accumulation of extracellular matrix, resulting in the loss of lung architecture and a decline of lung function, ultimately culminating in respiratory ...