Background The elimination of HBV covalently closed circular DNA (cccDNA) remains a critical hurdle for chronic hepatitis B (CHB) management. Objective In this investigation, we examined the efficacy ...

BACKGROUND: Direct reprogramming of fibroblasts to cardiomyocytes is a potentially curative strategy for ischemic heart ...

Organ transplantation offers life-saving treatment for patients with end-stage organ failure, restoring function and vastly ...

imageimageCD206+ macrophages promote skin wound healing by interacting with Gpnmbhi fibroblasts partly via the PDGFA-PDGFRA axis. Depletion of CD206+ macrophages alters fibroblast subpopulations, ...

FIGURE 1 Flow diagram showing methodology of software-assisted image analysis for quantification of centrilobular fibrosis and sinusoidal lumen ratio. The methodology starts from the glass slide ...

Yoda1 has been recognized as an effective pharmacological intervention for the treatment of critical bone defects. However, the local delivery strategy of Yoda1 is uncommon, and the underlying ...

The foreign body response to implants leads to chronic inflammation and fibrosis that can be highly variable in the general patient population. Here, we demonstrate that gut dysbiosis via enteric ...

Elevated levels of the profibrotic genes Acta2, Col1a1, and Col3a were exclusively detected in this group at 3 weeks, and trichrome staining confirmed increased collagen content after 3 weeks. Both ...

E) Representative liver section staining by Masson’s Trichrome in control or C3aR1-KpKO male mice (scale bar = 100 mm). F) Lipid droplet area quantified on liver sections of control or C3aR1-KpKO male ...

Microplastics are ubiquitous environmental contaminants for which there are documented human exposures, but there is a paucity of research evaluating their impacts on human health. We conducted a ...

Nervonic acid as novel therapeutics initiates both neurogenesis and angiogenesis for comprehensive wound repair and healing ...