Translation is the process by which a protein is synthesized from the information contained in a molecule of messenger RNA (mRNA). During translation, an mRNA sequence is read using the genetic ...

Only recently has the ribosome—one of the oldest molecular machines in evolutionary terms—been recognized as an active ...

The research field of "cellular IRESes" lay dormant for decades, as there was no uniform standard of reliable methods for the clear characterization of these starting points for the ribosome-mediated ...

Transfer ribonucleic acid (tRNA) is a type of RNA molecule that helps decode a messenger RNA (mRNA) sequence into a protein. tRNAs function at specific sites in the ribosome during translation ...

is a new take on these RNA-imaging tools based on naturally occurring RNA sequences, called riboswitches, that fold robustly in the cellular environment and bind their ligands tightly and specifically ...

Certain mRNA sequences present challenges during translation ... shows ribosomes becoming brighter as they actively translate RNA. The team has already uncovered new insights using this approach.

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

With the long-term goal of creating living cells from non-living components, scientists in the field of synthetic biology work with RNA origami. This tool uses the multifunctionality of the natural ...

The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA ... rather than the full ~20 nucleotide sequence. 1 This means miRNA guides can target any mRNA ...

The key structural features of tRNA include: The specificity of tRNA-amino acid interactions and the accuracy of codon-anticodon recognition ensure the faithful translation of the genetic code into ...

For natural cells, the so-called central dogma of molecular biology describes how protein synthesis occurs through transcription and translation ... folding RNA alone. First, a DNA sequence ...