Spliceosome structures have been investigated extensively in the past decade, but most of the studies have been restricted to a handful of model organisms. New research by Lu et al, looks outside this ...

Proper splicing requires efficient spliceosome assembly ... The cis-regulatory elements encoded in the sequence and structure of mRNAs determine their translational output. Here the authors ...

An international research team led by Dr. Zhang Suinan from the Shanghai Astronomical Observatory of the Chinese Academy of ...

Biological cells often possess thin, hair-like protrusions on their surface known as cilia, which serve various functions ranging from movement to sensing environmental signals. Researchers from ...

Mitochondria are the powerhouses in our cells, producing the energy for all vital processes. Using cryo-electron tomography, ...

Aided by two molecular control factors, the spliceosome rejects pre-mRNA that could be incorrectly spliced. While GPATCH1 detects the defective pre-mRNA, DHX35 removes it from the spliceosome ...

This important study shows, for the first time, the structure and snapshots of the dynamics of the full-length soluble Angiotensin-I converting enzyme dimer. The combination of structural and ...

Four qualities that elevate this paper from good to great in style are: its structure, captivity, soulfulness, and precision. Structured Outline, Paragraphs, and Sentences Structurally ...

Aided by two molecular control factors, the spliceosome rejects pre-mRNA that could be incorrectly spliced. While GPATCH1 detects the defective pre-mRNA, DHX35 removes it from the spliceosome ...

The spliceosome, which forms on introns, is composed of proteins and noncoding RNAs called small nuclear RNAs (snRNAs). In the first step of spliceosome assembly, an snRNA molecule known as U1 ...