Blaustein and colleagues concluded that activation of the PI 3-kinase signaling pathway by Ras(V12-C40) in turn activated AKT kinase, resulting in a change in the fibronectin splicing pattern to ...

Shown is the splicing pathway. The pre-messenger RNA (pre-mRNA) has exons (blue) and introns (pink). The spliceosome (not shown) was known to catalyze two chemical reactions (black arrows ...

Cells have a natural editing system that allows them to rearrange genetic instructions to create different proteins from the ...

Defining where to start cutting out the introns is just the first step in the spliceosome's complex assembly pathway. At least a dozen other steps are needed before the splicing reaction concludes.

Plants survive cold by adjusting at cellular level. Scientists discovered that the PORCUPINE protein helps plants adapt to ...

This RNA-RNA interaction is important for recognizing and committing the pre-mRNA to the splicing pathway. However, it is not sufficient to determine ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

Cellular reprogramming is an intrinsic evolutionary trait to constantly promote adaptations that confer survival advantage.

Her research reveals that this protein is part of multiple intertwined signaling pathways that help plants ... an essential part of this puzzle: RNA splicing, a process that determines which ...