Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Our knowledge of RNA splicing is quite new. Nonetheless, because nearly all eukaryotes have introns and share mechanisms of RNA splicing, splicing itself must be quite ancient. Proponents of the ...

Stay up to date on the latest science with Brush Up Summaries. Despite its significance, alternative splicing’s global impact on cellular homeostasis and intricate molecular mechanisms remains ...

Chen, M. & Manley, J. L. Mechanisms of alternative splicing regulation: Insights from molecular and genomics approaches. Nature Reviews Molecular Cell Biology 10, 741–754 (2009) doi:10.1038/nrm2777.

The mechanisms and physiological consequences of alternative splicing transitions during mammalian postnatal development The disruption of this regulatory network that is the pathogenic mechanism of ...

tRNA splicing occurs in two stages ... requirement for a 2’-PO 4 in the ligation step of fungal/plant tRNA ligase; (ii) developing a kinetic mechanism for the healing and sealing steps; (iii) ...

Previously my research centered on pre-mRNA splicing mechanisms in the nematode, C. elegans. We discovered that numerous operons exist in the genome of this animal.

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with poor prognosis, and understanding the ...

The pathogenic mechanism is disruption of developmentally regulated RNA processing, primarily alternative splicing, in which failure to express adult splicing patterns causes primary features of the ...