These circular RNAs are generated when the pre-mRNA splicing machinery “backsplices ... SR proteins, core spliceosome, and transcription termination factors that control the outputs of reporter and ...

We defined SERBP1’s interactome, uncovered novel roles in splicing, cell division and ribosomal biogenesis ... SERBP1 interacts with PARP1 and its associated factors and influences PARylation.

Conditional knockout studies and transcriptomic analyses have identified key transcription factors governing cochlear ... Mutations affecting the core splicing machinery can also cause disease. Since ...

In addition, mutations in splicing factors and U snRNAs are also linked to many human cancers and affect the splicing of many mRNAs. Our group recently discovered that one of the components of the ...

Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...