In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron. Until now, it had been thought that the binding strength ...

Spliceosome structures have been investigated extensively in the past decade, but most of the studies have been restricted to ...

In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron. Until now, it had been thought that the binding strength ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

This process is mediated by the spliceosome, a cellular complex composed of both RNA ... "Early studies demonstrated that one of the RNAs--the small nuclear RNA (snRNA) U1--base-pairs with the 5_ ...

How does the cell select this information? A large molecular machine called the spliceosome continuously separates the coding and non-coding regions of our genes – and it's doing this even as ...