In this Review, we discuss aspects of spliceosome assembly, transcription elongation and other co-transcriptional events that allow the temporal coordination of co-transcriptional splicing.

In search of the mechanism of ATM activation by transcription-blocking lesions, the authors hypothesized that spliceosome displacement would result in the formation of RNA–DNA hybrids (R-loops ...

About 10 years ago, researchers discovered a mechanism in animals that keeps the transcription of DNA to RNA running: telescripting. "The U1 snRNP complex has a dual function: as part of the ...

Graphic: Courtesy of Scott Stevens ASSEMBLY INSTRUCTIONS: In the penta-snRNP model, all five spliceosomal snRNPs interact with the substrate pre-mRNA as a single, discrete particle. Spliceosome ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

Researchers at the Centre for Genomic Regulation (CRG) have created the first blueprint of the human spliceosome, the complex molecular machine that edits genetic messages transcribed from DNA ...

How this system of broken genes and the spliceosome evolved in our genomes is not known. Over his long career, Manuel Ares, UC Santa Cruz distinguished professor of molecular, cellular, and ...

Transcription is the first step in the synthesis of proteins from specific gene sequences. ... The proteins in the spliceosome recognize and bind to the splice sites at the 3’ and 5’ end of ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

Introns are perhaps one of our genome's biggest mysteries. They are DNA sequences that interrupt the sensible protein-coding information in your genes, and need to be 'spliced out.' ...

Romancing the Spliceosome to Fight Spinal Muscular Atrophy. Author: Kathryn J. Swoboda, ... in which transcription was up-regulated or down-regulated by more than a factor of 2, ...