The ability to analyze gene expression at the single-cell level—known as single-cell RNA sequencing (scRNA-seq)—has ...

Scientists at St. Jude Children's Research Hospital have reconciled two closely related but contentious mechanisms underlying ...

The eukaryotic cell emerged as an evolutionary algorithmic phase transition Eukaryogenesis happened abruptly, led by the tension of increasing gene length and the constraints on producing longer ...

The correlation between promoter activity and the choice of the exon that will be the first in the mature mRNA could be interpreted as an interaction between transcription and splicing (the coupling ...

Cell Biochemistry Section at the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States; A key but often overlooked step in gene regulation is ...

The major spliceosome is abundant in cells and has been extensively investigated for more than four decades. Its long-separated twin – the minor spliceosome, is much more scarce and remains enigmatic, ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") – and about 150 proteins, involved in different stages ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

The research article, titled "Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome," represents a significant advancement in understanding the ...

First Spliceosome Blueprint Reveals Complex Interplay, Uncovers Drug Targets October 31, 2024 ...