Oncogenic MYC leads to an increase in pre-mRNA synthesis, and inhibition of the spliceosome impairs the growth and tumorigenicity of MYC-dependent breast cancer cells.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

The team at the CRG altered the expression of 305 spliceosome-related genes in human cancer cells one by one, observing the effects on splicing across the entire genome.

Previously unknown driver of prostate cancer identified "We took a closer look at a certain molecular machine called the spliceosome ", explains Anke Augspach, lead author of the study and ...

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukemia and breast cancer.

Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell.

A number of compounds, derived from bacterial fermentation products, have been found to target subunits of the spliceosome and display anticancer properties. In this Review, Valcárcel and ...

This effort, which was performed in a cancer cell culture model, indicated that various parts of the spliceosome have different regulatory functions, each of which carries out specific jobs that can ...

In their investigations, the team found various indications for the central role of the minor spliceosome in cancer. "We were able to show that a specific component of the minor spliceosome is ...

In addition to proteins, the spliceosome is also composed of small nuclear RNAs (snRNAs) that are responsible for splice site recognition and were long thought to be basal elements of the spliceosome.

The team at the CRG altered the expression of 305 spliceosome-related genes in human cancer cells one by one, observing the effects on splicing across the entire genome.