In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

and U5 snRNPs). How exactly these blocks assemble to build the minor spliceosome and help it fulfil its function remains elusive. Structures of large molecular machines are notoriously difficult to ...

With the participation of U5, the 3′ end of the intron is brought ... creating new proteins without disrupting the function of the old gene. Our knowledge of RNA splicing is quite new.

During splicing, U4/U6.U5 normally ensures the immediate ... types of cancer that are highly dependent on the correct function of the spliceosome." Some highly aggressive tumors produce large ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a ...

Splicing is a basic requirement for producing proteins that fulfill an organism’s vital functions. Faulty functioning of a spliceosome can lead to a variety of serious diseases. Researchers at ...