The minor spliceosome has a similar architecture, but its main building blocks are different (U11, U12, U4atac, U6atac, and U5 snRNPs). How exactly these blocks assemble to build the minor spliceosome ...

The minor spliceosome has a similar architecture, but its main building blocks are different (U11, U12, U4atac, U6atac, and U5 snRNPs). How exactly these blocks assemble to build the minor spliceosome ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") – and about 150 proteins, involved in different stages ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") -- and about 150 proteins, involved in different stages of ...

The minor spliceosome has a similar architecture, but its main building blocks are different (U11, U12, U4atac, U6atac, and U5 snRNPs). How exactly these blocks assemble to build the minor spliceosome ...

During splicing, U4/U6.U5 normally ensures the immediate and correct re-joining of loose ends after a transcript has been cut. Without USP39, or when subunits are mutated, this re-joining is delayed.

USP39 stabilizes the spliceosome (green), which cuts out unneeded parts (grey and purple) of the mRNA. If USP39 is missing, some of the mRNA is poorly processed. This results in misfolded proteins ...

In 1996, they were assigned functions in the splicing of minor-class introns (5, 6), and the U4atac and U6atac snRNAs of the minor spliceosome were identified (7). Thus, although four snRNPs are ...

Journal Reference: Dimitrije Stanković, Luke S Tain, Mirka Uhlirova. Xrp1 governs the stress response program to spliceosome dysfunction. Nucleic Acids Research, 2024; DOI: 10.1093/nar/gkae055 ...