The Galej Group at EMBL Grenoble has provided new insights into minor spliceosome function, revealing the structure of U11 snRNP - one of its subunits, which initiates the intron selection process. In ...

Researchers have revealed the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process.

Researchers unveil detailed structural insights into the minor spliceosome, shedding light on its role in gene expression and potential disease implications. ... Researchers have revealed the ...

In this new study, the researchers reveal the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process. Stitching gene pieces together ...

In this new study, the researchers reveal the structure of U11 snRNP -- one of the five subunits of the minor spliceosome, which initiates the intron selection process. Stitching gene pieces together ...

The spliceosome then converts them into mature, functional mRNA. To do this, this large protein-RNA complex, which is located in the cell nucleus, removes non-coding sections (introns) from mRNA ...

Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology , 2025; DOI: 10.1038/s41594-024-01480-7 Cite This Page : ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

Despite numerous efforts such as enhancing the video structure, uneven encoding, and filtering frames captured on camera, these methods have proven insufficient to address the challenges at hand. We ...

The structure of a single protein is already intricate, but the spliceosome, with its 300 components, is even more formidable. “And the same protein has different conformations and interactions at ...

Here, we present a cryo-EM structure of a step II catalytically activated spliceosome (C * complex) derived from the unicellular green alga Chlamydomonas reinhardtii at 2.6 Å resolution. This ...