RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, ...

Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that ...

Defining where to start cutting out the introns is just the first step in the spliceosome's complex assembly pathway. At least a dozen other steps are needed before the splicing reaction concludes.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Researchers have revealed the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process.

EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, first decided to focus on the minor spliceosome seven years ago – a project ...