Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

The fit between a splice site and the spliceosome components that bind it influences splicing activity. Strong splice sites closely match consensus sequences and are efficiently recognized by the ...

EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, first decided to focus on the minor spliceosome seven years ago. When the ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read “snurps”) – and about 150 proteins, involved in different stages of the ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

Splicing is a basic requirement for producing proteins that fulfill an organism’s vital functions. Faulty functioning of a spliceosome can lead to a variety of serious diseases. Researchers at ...