For patients with mutated SF3B1 or who did not have SF3B1 mutation, the luspatercept arms did better. For patients who had ring sideroblast–positive MDS, they clearly did better. For patients who were ...

Myelodysplastic syndromes and other cancers are often associated with mutations in the U2 snRNP protein SF3B1. Common SF3B1 mutations, including K700E, disrupt SF3B1 interaction with the protein SUGP1 ...

Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology , 2025; DOI: 10.1038/s41594-024-01480-7 Cite This Page : ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukemia, and breast cancer. It is also a target for anti-cancer ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukaemia and breast cancer. It is also a target for anti-cancer ...

One of her main conclusions is that the 300 components of the spliceosome are so interconnected that the failure of one can trigger a domino effect. The researchers manipulated the SF3B1 component, ...

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukaemia and breast cancer.

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukemia and breast cancer.