The eukaryotic cell emerged as an evolutionary algorithmic phase transition Eukaryogenesis happened abruptly, led by the tension of increasing gene length and the constraints on producing longer ...

A new study found that aged neurons have defects in key proteins that make them vulnerable to molecular stress and neurodegenerative damage.

Differentiated PH1 payload is a spliceosome inhibitor designed to inhibit RNA splicing, leading to cancer cell death and activation of immune system through multiple mechanisms India represents a key ...

Autism symptoms and new approaches to treatment. Read current research on autism including early diagnosis of autism spectrum disorders, genetic factors and more.

Upper panel (left to right) Dr. Mani Menon, Dr. Mahendra Bhandari, Dr. Rajvir Dahiya (President SAASRC); Dr, Dharam Paul Chauhan (Secretary SAASCR); Dr. Badrinath R. Konety, and Dr. Ravindra ...

During the transition from intron-containing precursor messenger RNA (pre-mRNA) to mature mRNA (mRNA), introns are removed and the flanking exons joined. Splice sites define the exon/intron boundaries ...

Akari Therapeutics Bolsters Global IP Estate for its Novel Antibody Drug Conjugate (ADC) Immuno-Oncology Payload, PH1, with Recent Granting of Patent Protection Across IndiaDifferentiated PH1 payload ...

Our finding that the spliceosome deposits a multi‐protein complex 20‐‐24 nt upstream of exon–exon junctions on multiple mRNAs was unexpected. Not only is there is no consensus sequence in this region, ...

ConspectusIntron removal from premature-mRNA (pre-mRNA splicing) is an essential part of gene expression and regulation that is required for the production of mature, protein-coding mRNA. The ...

NB in the high-E2F group presented increased activity in the spliceosome, ATP-dependent chromatin remodeling, and other pathways related to genome regulation (Figures 7A, B). To analyze the tumor ...