Splicing is catalyzed by a large molecular machine. This spliceosome is made up of variety of protein and RNA components, and for each splicing process, it is reassembled at the sites where an ...

Proper splicing requires efficient spliceosome assembly. Here the authors reveal that zinc finger protein 207 interacts with the U1 small nuclear ribonucleoprotein to accelerate spliceosome ...

The spliceosome, which forms on introns, is composed of proteins and noncoding RNAs called small nuclear RNAs (snRNAs). In the first step of spliceosome assembly, an snRNA molecule known as U1 ...

Silencing NOTCH1 and SF3B1 using chitosan lactate nanoparticles (CL-NPs) loaded with small interfering RNAs (siRNAs) significantly enhanced efficacy of paclitaxel in chronic lymphocytic leukemia (CLL) ...

Spliceosome structures have been investigated extensively in the past decade, but most of the studies have been restricted to a handful of model organisms. New research by Lu et al, looks outside this ...

Erythroblasts possess unique characteristics as they undergo differentiation from hematopoietic stem cells. During terminal erythropoiesis, these cells incorporate large amounts of iron in order to ...