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Discover how bitter taste receptors in the intestines affect aging. A new study identifies specific receptors linked to metabolic changes, inflammation, and lipid metabolism. Learn how these ...

The neonatal Fc receptor (FcRn) is a developmentally regulated, major histocompatibility complex class I –related molecule that binds IgG and albumin in a pH-dependent manner.

Led by Mark Bear, PhD, at MIT’s Picower Institute for Learning and Memory, the study builds on previous work by this group exploring the role of NMDA receptors in regulating synaptic plasticity ...

Additionally, their research may explain why high consumption of artificially sweetened beverages is linked to arrhythmogenesis, or an irregular heartbeat. Not only are these sweet taste receptors ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") – and about 150 proteins, involved in different stages ...

Heidelberg University. "Spliceosome: How cells avoid errors when manufacturing mRNA." ScienceDaily. ScienceDaily, 7 February 2025. <www.sciencedaily.com / releases / 2025 / 02 / 250207122612.htm>.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

LDLR: An ApoE Gateway Researchers have long known that ApoE2 binds weakly to low-density lipoprotein receptor. But many have assumed that if that were important for AD pathology, then the high-risk ...

High-resolution microscopic images of T cells that have been engineered with TGF-beta SNIPRs (shown in red) as they bind to TGF-beta (shown in green). The SNIPRs activate once the receptors fold into ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules which orchestrate the editing process, but until now, the specific roles of its numerous components were not ...