In a study published on Thursday, scientists revealed 4,208 previously unknown proteins that are made by viruses such as influenza and H.I.V. Researchers elsewhere have been uncovering thousands ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

A new regulatory mechanism in RNA splicing has been identified, involving LUC7 proteins that influence spliceosome targeting of specific 5' splice sites. This regulation affects about half of ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") -- and about 150 proteins, involved in different stages of ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") – and about 150 proteins, involved in different stages ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology, 2025; DOI: 10.1038/s41594-024-01480-7 ...

Splicing is a basic requirement for producing proteins that fulfill an organism’s vital functions. Faulty functioning of a spliceosome can lead to a variety of serious diseases.

This process is crucial for the life of the cell. "The spliceosome is composed of multiple components that secure production of functional proteins controlling cellular life," explains Đikić.

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules which orchestrate the editing process, but until now, the specific roles of its numerous components were not ...