In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

Splicing is a basic requirement for producing proteins that fulfill an organism's vital functions. Faulty functioning of a spliceosome can lead to a variety of serious diseases. The genetic ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

Jiangfeng Zhao, postdoctoral fellow in the Galej Group and the first author of the study Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits ...

Then the RNA binding protein communicates to the splicing machinery to include or not include the exon into the mRNA,” Cooper explained. The fit between a splice site and the spliceosome components ...

Splicing is a basic requirement for producing proteins that fulfill an organism’s vital functions. Faulty functioning of a spliceosome can lead to a variety of serious diseases. Researchers at ...