A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology.

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology , 2025; DOI: 10.1038/s41594-024-01480-7 Cite This Page : ...

Nature Chemical Biology - The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b ...

The sheer number of components involved and the intricacy of its function has meant the spliceosome has remained elusive and uncharted territory in human biology – until now. The blueprint reveals ...

Nature Structural & Molecular Biology - Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine Skip to main content Thank you for visiting nature.com.

Graphic: Courtesy of Scott Stevens ASSEMBLY INSTRUCTIONS: In the penta-snRNP model, all five spliceosomal snRNPs interact with the substrate pre-mRNA as a single, discrete particle. Spliceosome ...

"RBM5 helps to bring the spliceosome to the mRNA by binding to a spliceosomal protein,” explains coauthor Dr. Sophie Bonnal of the CRG Barcelona. The researchers determined that RBM5 controls the ...

Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology. The vast majority of human genes -- more than nine in ten ...