Reference: “Structural insights into spliceosome fidelity: DHX35–GPATCH1- mediated rejection of aberrant splicing substrates” by Yi Li, Paulina Fischer, Mengjiao Wang, Qianxing Zhou, Aixia Song, Rui ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

We integrated this reporter into the AAVS1 safe harbor locus of HCT116 cells by TALEN-mediated recombination and isolated clonal cell lines harboring the reporter (26). Treatment of cells with the OGA ...

The research article, titled "Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome," represents a significant advancement in understanding the ...

“We report transcriptome-wide analyses upon systematic knock down of 305 spliceosome components and regulators in human cancer cells and the reconstruction of functional splicing factor networks ...

Site-directed mutagenesis of ATM target sites prevented IGF-1-mediated release from the spliceosome and skewed the survivin splicing output toward survivin-2B. Conclusion: These data uncover a novel ...

Scientists have uncovered the inner workings of one of the most important and intricate ‘nanobots’ operating within our cells – using cutting-edge microscopy for visualising molecules almost at an ...

Spliceosome-mediated RNA trans-splicing (SMaRT) - gene reprogramming system designed to correct aberrantly spliced mRNAs by replacing the entire coding sequence upstream or downstream of a splice site ...

Spliceosome-mediated RNA trans-splicing (SMaRT) -- gene reprogramming system designed to correct aberrantly spliced mRNAs by replacing the entire coding sequence upstream or downstream of a splice ...

Spliceosome-mediated RNA trans-splicing (SMaRT) - gene reprogramming system designed to correct aberrantly spliced mRNAs by replacing the entire coding sequence upstream or downstream of a splice site ...