RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns, splicing ...

Nucleases are hydrolytic enzymes (hydrolases) that cleave the phosphodiester bond between nucleotides within nucleic acids, either within the nucleic acid chain (as in endonucleases) or from the ...

Roche’s gene therapy unit Spark has added to its pipeline in inherited retinal diseases (IRDs) with a $216 million alliance with Spanish biotech SpliceBio. Under the terms of th ...