Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome ...

EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, first decided to focus on the minor spliceosome seven years ago.

The spliceosome is the collection of 150 different proteins and five small RNA molecules which orchestrate the editing ... One of the ways cancers adapt is by rewiring their splicing machinery.

“The spliceosome is the complex molecular machinery that sequentially assembles on eukaryotic messenger RNA precursors to remove introns (pre-mRNA splicing), a physiologically regulated process ...

The major spliceosome consists of five subunits, U1, U2, U4, ... EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, ...

Makishima, H. et al. Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis. Blood 119 , 3203–3210 (2012). Article CAS PubMed PubMed Central Google Scholar ...

Leukemia - Mutations of epigenetic regulators and of the spliceosome machinery in therapy-related myeloid neoplasms and in acute leukemias evolved from chronic myeloproliferative diseases ...

This process requires the complex cellular machinery known as the spliceosome. A process known as alternative mRNA splicing can result in dozens of different mRNA species from a single pre-mRNA ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...