The debate over gain of function research sharpened during the pandemic. Mr. Trump and other elected officials have linked such research to the origin of Covid, claiming that Chinese researchers ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") – and about 150 proteins, involved in different stages ...

The spliceosome is critical for the proper functioning of every cell, and numerous genetic disorders are linked to problems with spliceosome function.

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

The Galej Group at EMBL Grenoble has provided new insights into minor spliceosome function, revealing the structure of U11 snRNP – one of its subunits, ...

This effort, which was performed in a cancer cell culture model, indicated that various parts of the spliceosome have different regulatory functions, each of which carries out specific jobs that can ...

Their work revealed that different components of the spliceosome have unique regulatory functions. Crucially, they found that proteins within the spliceosome’s core are not just idle support workers ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology.

The scientists’ work revealed that different components of the spliceosome have unique regulatory functions. “Collectively, our results demonstrate how systematic, ...

Biomacromolecules in cells often form protein machineries or complexes to function. The spliceosome is a prime example: To execute pre-mRNA splicing, hundreds of spliceosomal components must recognize ...

Biomacromolecules in cells often form protein machineries or complexes to function. The spliceosome is a prime example: To execute pre-mRNA splicing, hundreds of spliceosomal components must recognize ...

The spliceosome is the molecular machine in our cells that puts the blueprints for proteins into a readable form. Researchers at the Max Planck Institute (MPI) for Multidisciplinary Sciences in ...