A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps ...

Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology , 2025; DOI: 10.1038/s41594-024-01480-7 Cite This Page : ...

Researchers at the Centre for Genomic Regulation (CRG) have created the first blueprint of the human spliceosome, the complex molecular machine that edits genetic messages transcribed from DNA ...

The spliceosome does the genetic cutting and pasting. It is a complicated complex, made up of four major parts and more than 100 accessory proteins that come together and break apart throughout ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

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After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

How this system of broken genes and the spliceosome evolved in our genomes is not known. Over his long career, Manuel Ares, UC Santa Cruz distinguished professor of molecular, cellular, and ...