This means that a spliceosome discarded during cellular quality control can be represented at the atomic level for the first ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, ...

The fit between a splice site and the spliceosome components that bind it influences splicing activity. Strong splice sites closely match consensus sequences and are efficiently recognized by the ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

and we hope that this and future work will contribute to a better understanding of the molecular basis of the genetic disorders associated with the components of the minor spliceosome. This could ...

“However, analyzing the components flexibly bound to the periphery of the spliceosome was a major challenge for our work,” explains Dr Komal Soni from the BZH. Based on this structural ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that ...

RNA splicing is crucial for gene expression. After DNA is copied into messenger RNA (mRNA), noncoding parts called introns are removed, and the coding parts are spliced together.