A new study found that aged neurons have defects in key proteins that make them vulnerable to molecular stress and neurodegenerative damage.

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") – and about 150 proteins, involved in different stages ...

The team at the CRG altered the expression of 305 spliceosome-related genes in human cancer cells one by one, observing the effects on splicing across the entire genome. Their work revealed that ...

Their work revealed that different components of the spliceosome have unique regulatory functions. Crucially, they found that proteins within the spliceosome’s core are not just idle support workers ...

The structure of a single protein is already intricate, but the spliceosome, with its 300 components, is even more formidable. “And the same protein has different conformations and interactions at ...

This collaborative effort led to several significant discoveries, including the unexpected finding that different protein components of the U1 snRNP complex, a well-studied ribonucleoprotein complex ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules which orchestrate the editing process, but until now, the specific roles of its numerous components were ...

WATERTOWN, Mass., Oct. 31, 2024 /PRNewswire/ -- Remix Therapeutics (Remix), a clinical-stage biotechnology company developing sm ...

Remix Therapeutics (Remix), a clinical-stage biotechnology company developing small molecule therapies to modulate RNA processing and address underlying drivers of disease, today announced the ...