In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

This means that a spliceosome discarded during cellular quality control can be represented at the atomic level for the first time. "However, analyzing the components flexibly bound to the ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a ...

and we hope that this and future work will contribute to a better understanding of the molecular basis of the genetic disorders associated with the components of the minor spliceosome. This could ...

The fit between a splice site and the spliceosome components that bind it influences splicing activity. Strong splice sites closely match consensus sequences and are efficiently recognized by the ...

“However, analyzing the components flexibly bound to the periphery of the spliceosome was a major challenge for our work,” explains Dr Komal Soni from the BZH. Based on this structural ...