Proteins are the infinitely varied chemicals that make cells work, and science has a pretty good idea how they are made. But ...

Cornell researchers have found a new and potentially more accurate way to see what proteins are doing inside living ...

Micrometeorites are thought to shower down on planets throughout the universe, so the discovery that they help protocells ...

When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

Defining where to start cutting out the introns is just the first step in the spliceosome's complex assembly pathway. At least a dozen other steps are needed before the splicing reaction concludes.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona, a BIST Community centre, have created the first blueprint of the human spliceosome, the most complex and intricate molecular ...

This collaborative effort led to several significant discoveries, including the unexpected finding that different protein components of the U1 snRNP complex, a well-studied ribonucleoprotein complex ...

First Spliceosome Blueprint Reveals Complex Interplay, Uncovers Drug Targets October 31, 2024 ...

During pre-mRNA splicing, DDX23’s ATPase activity is essential for the pre-B to B spliceosome complex transition and for release of U1 snRNP from the 5′ splice site. We show that the RS-like region of ...