When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

Splicing twins: Unravelling the secrets of the minor spliceosome complex. European Molecular Biology Laboratory. Journal Molecular Cell DOI 10.1016/j.molcel.2024.12.017. Keywords ...

A specialized molecular complex known as the minor spliceosome removes some rare but critical introns, and several genetic disorders are associated with its dysfunction.

“The spliceosome is the complex molecular machinery that sequentially assembles on eukaryotic messenger RNA precursors to remove introns (pre-mRNA splicing), a physiologically regulated process ...

Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology. The vast majority of human genes -- more than nine in ten ...

A hPrp28 mutant stalls spliceosome assembly before complex B. To dissect the role of the DEAD-box protein hPrp28 during human spliceosomal B complex formation, we first assayed the effect of an ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

The spliceosome: An atomic-level look into how cells avoid errors when manufacturing mRNA. A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after ...

There are about a hundred proteins that comprise the spliceosome. But the gene just found to be so strongly associated with neurodevelopmental disorders doesn’t encode any of them.

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology.