A specialised molecular complex known as the minor spliceosome removes some rare but critical introns, and several genetic disorders are associated with its dysfunction. The Galej Group at EMBL ...

A specialized molecular complex known as the minor spliceosome removes some rare but critical introns, and several genetic disorders are associated with its dysfunction.

Splicing twins: Unravelling the secrets of the minor spliceosome complex. European Molecular Biology Laboratory. Journal Molecular Cell DOI 10.1016/j.molcel.2024.12.017. Keywords ...

When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

The spliceosome is a large and complex molecular machine within the cell that removes introns from pre-messenger RNA (pre-mRNA), allowing for the proper assembly of protein-coding sequences, or exons.

The spliceosome complex was found to be interconnected, with disruptions in one portion having significant effects on other parts of the complex. "Their reliance on a highly interconnected splicing ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona, a BIST Community centre, have created the first blueprint of the human spliceosome, the most complex and intricate molecular ...

The structure of a single protein is already intricate, but the spliceosome, with its 300 components, is even more formidable. “And the same protein has different conformations and interactions at ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology.

Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology. The vast majority of human genes -- more than nine in ten ...

“The spliceosome is the complex molecular machinery that sequentially assembles on eukaryotic messenger RNA precursors to remove introns (pre-mRNA splicing), a physiologically regulated process ...