The spliceosome is critical for the proper functioning of every cell, and numerous genetic disorders are linked to problems with spliceosome function. In most eukaryotic cells, two types of ...

Cellular activity hints that recycling is in our DNA New research shows that 'spliceosomes' might reinsert problematic gene sequences after removing them Date: May 10, 2024 Source: University of ...

The spliceosome is critical for the proper functioning of every cell, and numerous genetic disorders are linked to problems with spliceosome function. In most eukaryotic cells, two types of ...

Thus, spliceosome assembly is stalled during the A to B complex transition, indicating that hPrp28 activity is required at this stage.

Researchers unveil detailed structural insights into the minor spliceosome, shedding light on its role in gene expression and potential disease implications.

Conceivably, modulation of spliceosome activity — such as changes in the efficiency of the second catalytic step and of the release of splicing intermediates from the spliceosome complex ...

The spliceosome is critical for the proper functioning of every cell, and numerous genetic disorders are linked to problems with spliceosome function.

An international research team has uncovered a new mechanism crucial to the production of cellular proteins. When this mechanism is disrupted, the blueprints used by the cell to produce proteins ...

When minor spliceosome activity is reduced, the minor introns are retained in the mRNA while the major introns are spliced out. This signals the mRNA for degradation, limiting the expression of ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

Detailed map of the spliceosome is being made publicly available to help researchers pinpoint exactly where splicing errors are occurring in a patient's cells.