eIF4AIII binds directly to spliced mRNA. Using RNAs containing site-specific photocrosslinking moieties, we have previously reported that one of the strongest splicing-dependent crosslinks in the ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

Remarkably, mRNA acquires a complex of proteins at each exon–exon junction during pre-mRNA splicing that influences the subsequent steps of mRNA translation and nonsense-mediated mRNA decay.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

“And whenever a mistake occurs during splicing, you will find a disease as a result,” added Kevin Chung, a graduate student in the Pyle lab and co-author. Aberrant splicing of mRNA has been implicated ...

Pre-mRNA splicing in a subset of human short introns is governed by a distinct mechanism involving a new splicing factor, new research finds. Share: Facebook Twitter Pinterest LinkedIN Email.

Visualizing the machinery of mRNA splicing Date: April 8, 2008 Source: Yale University Summary: Recent research at Yale provided a glimpse of the ancient mechanism that helped diversify our ...

Researchers have long agreed that mRNA splicing takes place within the cell nucleus. In the nucleus of a mammalian cell, a gene is copied into mRNA, which possesses both exons ...

Pre-mRNA splicing in a subset of human short introns is governed by a distinct mechanism involving a new splicing factor Protein-coding genes carry the blueprint for protein production. In higher ...

A wide spectrum of cancer-associated genetic alterations, including those that result in changes to the splicing of pre–messenger RNA (mRNA), can lead to the presentation of aberrant peptides as ...

Alternative splicing enables a single gene to encode multiple mRNA variants and, consequently, diversifies protein isoform products. The advent of deep sequencing technologies has revealed that 95 ...

What remained unclear, however, was whether the spliceosome can recognize and reject a precursor mRNA with a non-authentic splice site,” explains Prof. Hurt. In studies with spliceosomes of the ...