EMBO Press1d
CD47-amyloid-β-CD74 signaling triggers adaptive immunosuppression in sepsis
CD47-amyloid-β-CD74 signaling is a key driver of adaptive immunosuppression in sepsis, suppressing B cells and impairing ...
FierceBiotech16d
BioNTech passes on Autolus' CD19/CD22 CAR-T amid pipeline prioritization
Building on its autologous CD19 CAR-T cell therapy obe-cel, Autolus added a CD22 CAR to create AUTO1/22. The dual mechanism is intended to address a major cause of treatment failure. Thursday ...
Frontiers16d
Immunosuppression of spleen in mice treated with erythropoietin: transcriptomic and immunological analysis
Pathological changes in histology were observed using Hematoxylin and Eosin ... which revealed a strong association between EPO-induced splenomegaly and immunosuppression of the spleen. This finding ...
BMJ1mon
OP0141 LONG TERM SAFETY AND EFFICACY OF CAR-T CELL TREATMENT IN REFRACTORY SYSTEMIC LUPUS ERYTHEMATOSUS - DATA FROM THE FIRST SEVEN PATIENTS
Recently, we reported that deep B cell depletion using a single infusion with autologous CD19 chimeric antigen receptor (CAR) T cells induced drug-free clinical remission in severe SLE patients with ...
Frontiers1mon
CD19 -targeted CAR T therapy treating hematologic malignancies: hidden danger is the next neighbor to security?
CD19-targeted chimeric antigen receptor (CAR) T-cell therapy has achieved marvelous results in the treatment of patients with relapsed and/or refractory B-cell lymphomas, B-cell acute lymphoblastic ...
Nature8y
Fully human CD19-specific chimeric antigen receptors for T-cell therapy
Impressive results have been achieved by adoptively transferring T-cells expressing CD19-specific CARs with binding domains from murine mAbs to treat B-cell malignancies. T-cell mediated immune ...