Proper splicing requires efficient spliceosome assembly. Here the authors reveal that zinc finger protein 207 interacts with the U1 small nuclear ribonucleoprotein to accelerate spliceosome ...

This process, called alternative RNA splicing, fine-tunes how proteins function ... Think of it as a self-destruct button ...

RGT-61159 is an orally available small molecule designed to specifically modulate splicing of the transcription ... regulator of cell proliferation, self-renewal, and differentiation processes ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

This study shows that RNA decay rather than the presence of premature termination codons triggers a TA-like response.

We might ask what kind of life is possible for someone after such self-destructive behavior. How can he move ahead knowing the harm he caused? He cannot reclaim the family he lost nor end the ...

The approach is to develop small-molecule drugs that can correct RNA mis-splicing, leading to loss of RNA expression by exon-skipping. It is another way to go after hard-to-target disease ...

As parents and supporters juggling countless competing demands, it can feel hard to find the time, energy, or resources to be able to look after ourselves. But our well-being isn’t just about us ...